Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model
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چکیده
منابع مشابه
Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model.
The number of animals used in science is increasing, bringing a concomitant obligation to minimize suffering. For animals with progressive conditions, euthanasia at a 'humane end point' is advised if the end point is scientifically valid, predictive and accurate. Our aim was to test the hypothesis that behavioural changes would reliably precede clinical signs of disease in a progressive neurolo...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society B: Biological Sciences
سال: 2008
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2008.0388